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Patents

Selected patents and patent applications arising from research in the Bathe BioNanoLab are listed below, newest first. Related continuations and issued patents are grouped by invention.

Method and System for Massively Parallel Integration of Diverse Nanomaterials Using Orthogonally-Encoded DNA Templates

J. Banal, M. Bathe, J. Gorman, G.A. Knappe, X. Luo
U.S. Provisional Patent Application No. 63/815,834, filed June 1, 2025.

Nucleic Acid Nanoparticle Delivery System for Targeted Delivery of Therapeutics and Vaccines to the Central Nervous System

M. Bathe, K.U. Dam, G.A. Knappe, R. Sirianni
U.S. Provisional Patent Application No. 63/808,429, filed May 19, 2025.

Compositions of Nucleic Acid Nanostructures for Vaccines and Methods of Use Thereof

M. Bathe, R. Veneziano, E.-C. Wamhoff, T. Moyer, B.J. Read, A. Romanov, G.A. Knappe, D.J. Irvine
U.S. Patent Application No. 19/257,179; US 2025/0387466 A1, filed July 1, 2025; published December 25, 2025. Pending.

Multimodal and Network Phenotyping Based on Single-Organelle In Situ Multiplexed Imaging

M. Bathe, R. Falkovich
U.S. Provisional Patent Application No. 63/706,172, filed October 11, 2024.

Rapid and Scalable Solution-Based Fabrication of Quantum Dot and Quantum Rod 2D Arrays Using DNA Origami

M. Bathe, R.J. Macfarlane, C. Chen, X. Luo
PCT/US2024/016144; WO 2024/186458, filed February 16, 2024; priority February 17, 2023. U.S. and international applications pending.

Nucleic Acid Nanostructure Platform for Programming Immune Stimulation

M. Bathe, R. Veneziano, E.-C. Wamhoff, T. Moyer, B.J. Read, R. Du, D.J. Irvine
U.S. 12,642,850 B2, issued June 2, 2026.

RNA Scaffolded Wireframe Origami and Methods Thereof

M. Bathe, T. Shepherd, M.F. Parsons
U.S. Patent Application No. 18/191,723; US 2023/0302423 A1, published September 28, 2023. Pending.

Sequence-Controlled Polymer Storage

J.L. Banal, M. Bathe, J. Berleant, C.E. Leiserson, T.B. Schardl
U.S. Patent Application No. 17/836,726; US 2022/0396789 A1, published December 15, 2022. Pending.

DNA-Dye Assembly Based Single-Molecule Fluorescence Lifetime Imaging Probes

S.M. Hart, X. Wang, M. Bathe, G.S. Schlau-Cohen, J. Guo
PCT/US2022/078972; WO 2023/077119; U.S. published application US 2023/0295695 A1.

Nucleic Acid Nanostructure Platform for Antigen Presentation and Vaccine Formulations Formed Therefrom

M. Bathe, R. Veneziano, E.-C. Wamhoff, T. Moyer, B.J. Read, D.J. Irvine
U.S. 11,419,932 B2, issued August 23, 2022.

Nucleic Acid Assemblies for Use in Targeted Delivery

F. Zhang, T.R. Shepherd, R. Veneziano, M. Bathe, I. Slaymaker, B. Zetsche
PCT/US2019/050029; WO 2020/051507; U.S. Application No. 17/273,999; US 2021/0317479 A1.

Microbial Production of Pure Single-Stranded Nucleic Acids

T. Shepherd, R. Du, M. Bathe
U.S. 10,940,171 B2, issued March 9, 2021.

Automated Methods for Scalable, Parallelized Enzymatic Biopolymer Synthesis and Modification Using Microfluidic Devices

J. Banal, J.D. Berleant, T. Shepherd, M. Bathe
U.S. 11,851,651 B2, issued December 26, 2023. Continuation U.S. Application No. 18/506,027; US 2024/0076654 A1, pending.

Stable Nanoscale Nucleic Acid Assemblies and Methods Thereof

R. Veneziano, S. Ratanalert, T. Shepherd, H. Jun, M. Bathe
U.S. 11,410,746 B2, issued August 9, 2022.

Sequence-Controlled Polymer Random Access Memory Storage

M. Bathe, S. Ratanalert, R. Veneziano, J. Banal, T. Shepherd
U.S. 11,514,331 B2, issued November 29, 2022; US 11,961,008 B2, issued April 16, 2024. Continuation U.S. Application No. 18/589,141; US 2024/0211771 A1, pending.

Techniques for Controlling Spatial Structure of Nucleic Acid Structures Based on Lattice-Free, Three-Dimensional Junction Coordinates

M. Bathe, K. Pan, D.-N. Kim
U.S. 10,289,799 B2, issued May 14, 2019.

Method and Apparatus for Controlling Properties of Nucleic Acid Nanostructures

M. Bathe, D.-N. Kim, H. Dietz
U.S. 8,554,489 B2, issued October 8, 2013.

Bayesian Inference of Particle Motion and Dynamics from Single Particle Tracking and Fluorescence Correlation Spectroscopy

M. Bathe, J. He, S.-M. Guo, N. Monnier
U.S. 8,542,898 B2, issued September 24, 2013.

Patent status reflects publicly available records and may not include unpublished or recently filed applications.